Foundation models have transformed computational pathology by providing generalizable representations from large-scale histology datasets. However, existing models are predominantly trained on surgical pathology data, which is enriched for non-nervous tissue and overrepresents neoplastic, inflammatory, metabolic, and other non-neurological diseases. Neuropathology represents a markedly different domain of histopathology, characterized by unique cell types (neurons, glia, etc.), distinct cytoarchitecture, and disease-specific pathological features including neurofibrillary tangles, amyloid plaques, Lewy bodies, and pattern-specific neurodegeneration. This domain mismatch may limit the ability of general-purpose foundation models to capture the morphological patterns critical for interpreting neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and cerebellar ataxias. To address this gap, we developed NeuroFM, a foundation model trained specifically on whole-slide images of brain tissue spanning diverse neurodegenerative pathologies. NeuroFM demonstrates superior performance compared to general-purpose models across multiple neuropathology-specific downstream tasks, including mixed dementia disease classification, hippocampal region segmentation, and neurodegenerative ataxia identification encompassing cerebellar essential tremor and spinocerebellar ataxia subtypes. This work establishes that domain-specialized foundation models trained on brain tissue can better capture neuropathology-specific features than models trained on general surgical pathology datasets. By tailoring foundation models to the unique morphological landscape of neurodegenerative diseases, NeuroFM enables more accurate and reliable AI-based analysis for brain disease diagnosis and research, setting a precedent for domain-specific model development in specialized areas of digital pathology.

In the domain of combat simulations in support of wargaming, the development of intelligent agents has predominantly been characterized by rule-based, scripted methodologies with deep reinforcement learning (RL) approaches only recently being introduced. While scripted agents offer predictability and consistency in controlled environments, they fall short in dynamic, complex scenarios due to their inherent inflexibility. Conversely, RL agents excel in adaptability and learning, offering potential improvements in handling unforeseen situations, but suffer from significant challenges such as black-box decision-making processes and scalability issues in larger simulation environments. This paper introduces a novel hierarchical hybrid artificial intelligence (AI) approach that synergizes the reliability and predictability of scripted agents with the dynamic, adaptive learning capabilities of RL. By structuring the AI system hierarchically, the proposed approach aims to utilize scripted agents for routine, tactical-level decisions and RL agents for higher-level, strategic decision-making, thus addressing the limitations of each method while leveraging their individual strengths. This integration is shown to significantly improve overall performance, providing a robust, adaptable, and effective solution for developing and training intelligent agents in complex simulation environments.

Objective This study introduces the Alzheimer's Disease Common Data Element Ontology for Clinical Trials (AD-CDO), a lightweight, semantically enriched ontology designed to represent and standardize key eligibility criteria concepts in Alzheimer's disease (AD) clinical trials. Materials and Methods We extracted high-frequency concepts from more than 1,500 AD clinical trials on ClinicalTrials.gov and organized them into seven semantic categories: Disease, Medication, Diagnostic Test, Procedure, Social Determinants of Health, Rating Criteria, and Fertility. Each concept was annotated with standard biomedical vocabularies, including the UMLS, OMOP Standardized Vocabularies, DrugBank, NDC, and NLM VSAC value sets. To balance coverage and manageability, we applied the Jenks Natural Breaks method to identify an optimal set of representative concepts. Results The optimized AD-CDO achieved over 63% coverage of extracted trial concepts while maintaining interpretability and compactness. The ontology effectively captured the most frequent and clinically meaningful entities used in AD eligibility criteria. We demonstrated AD-CDO's practical utility through two use cases: (a) an ontology-driven trial simulation system for formal modeling and virtual execution of clinical trials, and (b) an entity normalization task mapping raw clinical text to ontology-aligned terms, enabling consistency and integration with EHR data. Discussion AD-CDO bridges the gap between broad biomedical ontologies and task-specific trial modeling needs. It supports multiple downstream applications, including phenotyping algorithm development, cohort identification, and structured data integration. Conclusion By harmonizing essential eligibility entities and aligning them with standardized vocabularies, AD-CDO provides a versatile foundation for ontology-driven AD clinical trial research.

Neural Radiance Fields (NeRFs) have demonstrated remarkable capabilities in 3D reconstruction and novel view synthesis. However, most existing NeRF frameworks require complete retraining when new views are introduced incrementally, limiting their applicability in domains where data arrives sequentially. This limitation is particularly problematic in satellite-based terrain analysis, where regions are repeatedly observed over time. Incremental refinement of NeRFs remains underexplored, and naive approaches suffer from catastrophic forgetting when past data is unavailable. We propose $Δ$-NeRF, a unique modular residual framework for incremental NeRF refinement. $Δ$-NeRF introduces several novel techniques including: (1) a residual controller that injects per-layer corrections into a frozen base NeRF, enabling refinement without access to past data; (2) an uncertainty-aware gating mechanism that prevents overcorrection by adaptively combining base and refined predictions; and (3) a view selection strategy that reduces training data by up to 47\% while maintaining performance. Additionally, we employ knowledge distillation to compress the enhanced model into a compact student network (20\% of original size). Experiments on satellite imagery demonstrate that $Δ$-NeRF achieves performance comparable to joint training while reducing training time by 30-42\%. $Δ$-NeRF consistently outperforms existing baselines, achieving an improvement of up to 43.5\% in PSNR over naive fine-tuning and surpassing joint training on some metrics.

QML-HCS is a research-grade framework for constructing and analyzing quantum-inspired machine learning models operating under hypercausal feedback dynamics. Hypercausal refers to AI systems that leverage extended, deep, or nonlinear causal relationships (expanded causality) to reason, predict, and infer states beyond the capabilities of traditional causal models. Current machine learning and quantum-inspired systems struggle in non-stationary environments, where data distributions drift and models lack mechanisms for continuous adaptation, causal stability, and coherent state updating. QML-HCS addresses this limitation through a unified computational architecture that integrates quantum-inspired superposition principles, dynamic causal feedback, and deterministic-stochastic hybrid execution to enable adaptive behavior in changing environments. The framework implements a hypercausal processing core capable of reversible transformations, multipath causal propagation, and evaluation of alternative states under drift. Its architecture incorporates continuous feedback to preserve causal consistency and adjust model behavior without requiring full retraining. QML-HCS provides a reproducible and extensible Python interface backed by efficient computational routines, enabling experimentation in quantum-inspired learning, causal reasoning, and hybrid computation without the need for specialized hardware. A minimal simulation demonstrates how a hypercausal model adapts to a sudden shift in the input distribution while preserving internal coherence. This initial release establishes the foundational architecture for future theoretical extensions, benchmarking studies, and integration with classical and quantum simulation platforms.

Graft-versus-host disease (GVHD) is a rare but often fatal complication in liver transplantation, with a very high mortality rate. By harnessing multi-modal deep learning methods to integrate heterogeneous and imbalanced electronic health records (EHR), we aim to advance early prediction of GVHD, paving the way for timely intervention and improved patient outcomes. In this study, we analyzed pre-transplant electronic health records (EHR) spanning the period before surgery for 2,100 liver transplantation patients, including 42 cases of graft-versus-host disease (GVHD), from a cohort treated at Mayo Clinic between 1992 and 2025. The dataset comprised four major modalities: patient demographics, laboratory tests, diagnoses, and medications. We developed a multi-modal deep learning framework that dynamically fuses these modalities, handles irregular records with missing values, and addresses extreme class imbalance through AUC-based optimization. The developed framework outperforms all single-modal and multi-modal machine learning baselines, achieving an AUC of 0.836, an AUPRC of 0.157, a recall of 0.768, and a specificity of 0.803. It also demonstrates the effectiveness of our approach in capturing complementary information from different modalities, leading to improved performance. Our multi-modal deep learning framework substantially improves existing approaches for early GVHD prediction. By effectively addressing the challenges of heterogeneity and extreme class imbalance in real-world EHR, it achieves accurate early prediction. Our proposed multi-modal deep learning method demonstrates promising results for early prediction of a GVHD in liver transplantation, despite the challenge of extremely imbalanced EHR data.

Conventional planning units or urban regions, such as census tracts, zip codes, or neighborhoods, often do not capture the specific demands of local communities and lack the flexibility to implement effective strategies for hazard prevention or response. To support the creation of dynamic planning units, we introduce a planning support system with agentic AI that enables users to generate demand-oriented regions for disaster planning, integrating the human-in-the-loop principle for transparency and adaptability. The platform is built on a representative initialized spatially constrained self-organizing map (RepSC-SOM), extending traditional SOM with adaptive geographic filtering and region-growing refinement, while AI agents can reason, plan, and act to guide the process by suggesting input features, guiding spatial constraints, and supporting interactive exploration. We demonstrate the capabilities of the platform through a case study on the flooding-related risk in Jacksonville, Florida, showing how it allows users to explore, generate, and evaluate regionalization interactively, combining computational rigor with user-driven decision making.

A.2 provides the definitions of six predicates used A.3 provides implementation details of our models. Logic expression is the actual predicate logic constraints that we use in the model. T ask 1: Story Generation Input expression: Order(hated, stupid) & Order(stupid, insulting) & Order (insulting, punched) Logic expression: Order(hated, stupid) Order(stupid, insulting) Order (insulting, punched) T5: I had a crush on a man. I told him I was stupid. He hated me for insulting me.

We show that \emph{Sorting by Strip Swaps} (SbSS) is NP-hard by a polynomial reduction of \emph{Block Sorting}. The key idea is a local gadget, a \emph{cage}, that replaces every decreasing adjacency $(a_i,a_{i+1})$ by a guarded triple $a_i,m_i,a_{i+1}$ enclosed by guards $L_i,U_i$, so the only decreasing adjacencies are the two inside the cage. Small \emph{hinge} gadgets couple adjacent cages that share an element and enforce that a strip swap that removes exactly two adjacencies corresponds bijectively to a block move that removes exactly one decreasing adjacency in the source permutation. This yields a clean equivalence between exact SbSS schedules and perfect block schedules, establishing NP-hardness.

We investigate the application of large language models (LLMs) to construct credit networks from firms' textual financial statements and to analyze the resulting network structures. We start with using LLMs to translate each firm's financial statement into a credit network that pertains solely to that firm. These networks are then aggregated to form a comprehensive credit network representing the whole financial system. During this process, the inconsistencies in financial statements are automatically detected and human intervention is involved. We demonstrate that this translation process is effective across financial statements corresponding to credit networks with diverse topological structures. We further investigate the reasoning capabilities of LLMs in analyzing credit networks and determining optimal strategies for executing financial operations to maximize network performance measured by the total assets of firms, which is an inherently combinatorial optimization challenge. To demonstrate this capability, we focus on two financial operations: portfolio compression and debt removal, applying them to both synthetic and real-world datasets. Our findings show that LLMs can generate coherent reasoning and recommend effective executions of these operations to enhance overall network performance.